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The series consisted initially of smartphones and the first device, the Samsung Galaxy S, was announced in March 2010 and released for sale in June of that year. Since the introduction of the Samsung Galaxy Note in 2011, the Galaxy S line is Flagship Smartphone of the company.

Samsung later expanded the Galaxy S line to tablet computers with the announcement of the Galaxy Tab S in June 2014 and released the next month. As of April 2020, the latest smartphones in the Galaxy S series are the Samsung Galaxy S20, S20+ and S20 Ultra, all released on 6 March 2020, and the latest tablet is the Samsung Galaxy Tab S6 released on 31 July 2019.